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Engineered Nanotrap : High-efficiency enrichment system

Engineered Nanotrap is a sample enrichment technology that utilizes a porous membrane and extracted red blood cell membrane to separate and concentrate biomolecules based on their size and charge. By leveraging the unique properties of aquaporins and lipids, the technology enables precise control over the enrichment process. The tunability of the enrichment appears under different pressure conditions, and the squeezing characteristics of cells under specific pressures allow for efficient separation and concentration of biomolecules according to their size.

Technical Advantage

  • Enhanced
    Sensitivity

    Achieve up to 30-fold enrichment of desired biomolecules by perm-selectively separating them based on size and charge

  • Simplified Process work

    Two-Step Workflow
    1. Applying pressure to a sample contained within a dedicated cartridge
    2. Sample collection

  • Affordable

    Powered by hand pressure, eliminating the need for pumps and external power sources

  • Time savings

    Achieve a significant reduction in enrichment time to 3-5 minutes, compared to existing DNA/RNA prep kits.

Applications

  • · Enrichment and isolation of high-volume samples like urine and saliva

  • · Applicable to point-of-care (POC) testing for both immunoassays and molecular diagnostics due to its quick processing capabilities and high-yield sample preparation.

  • · Nanotrap enables the diagnosis of a wide range of diseases by facilitating the concentration of diverse biomolecules, including viruses, bacteria, antibodies, antigens, DNA, and RNA.

Patent

Sequence Patent name Registration (application) number
1 SELECTIVE CONCENTRATION FILTER BASE ON CELL MEMBRANE COMPONENT AND MANUFACTURING METHOD THEREOF 10-2022-0065520
2 SELECTIVE CONCENTRATION FILTER BASE ON CELL MEMBRANE COMPONENT AND MANUFACTURING METHOD THEREOF PCT/KR2022/014223

Publications

1. PCR-like performance of rapid test with permselective tunable nanotrap, Nat Commun. 2023, 14:1520

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